Investigating the Effects of TiO2 on the Structure and Properties of SiO2-P2O5-CaO-SrO-Na2O Based Glasses

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New York State College of Ceramics at Alfred University. Inamori School of Engineering.
Bioactive glasses have been researched and developed for dental and orthopedic applications since 1969. Current research has examined the substitution of non-traditional ions within the SiO2-CaO-Na2O-P2O5 which are suspected to improve the biological or material properties of bioactive glasses. This study examines four glass-ceramic compositions and the properties to understand the effects of increasing TiO2 concentration when substituted at 20, 40, and 60 mol % into a Bioglass based composition. Examining the structure of the glass shows that it is possible to achieve a fully amorphous material via melt quenching for concentrations up to 20 mol % TiO2. The thermal working range of the glasses is expanded with 20 mol % TiO2, 567 - 720°C, then the Tg window decreases as higher TiO2 concentrations are incorporated into the glass, 605 - 705°C and 635 - 717°C for 40 and 60 mol % respectively. The mechanical strength is affected by the sintering temperature with 800°C for the 20 mol % TiO2 best matching trabecular bone strength with a modulus of 1.79(±0.16) GPa. Ionic release is negatively impacted by the addition of TiO2, limiting the use of high TiO2 compositions as a bioactive material. Comparison of the 0 mol % and 20 mol % samples show a slower release of ions and consequently deposition of ions in a manner that suggest bioactivity with incorporation of TiO2 into the glass.
Thesis completed in partial fulfillment of the requirements for the degree of Master of Science in Biomaterials Engineering at the Inamori School of Engineering, New York State College of Ceramics at Alfred University
Bioactive glasses, Glass-ceramics