Characterization, Bioactivity and Antioxidant Capacity of Yttrium and Cerium Doped Glass-Ceramics

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New York State College of Ceramics at Alfred University. Kazuo Inamori School of Engineering.
Compositional modifications of traditional bioactive glasses were investigated to address adversity associated with the biological response after spinal cord injury (SCI); specifically the accumulation of calcium (Ca) and subsequent generation of reactive oxygen species (ROS). Studies have shown yttria and ceria to have direct antioxidant scavenging capacity and provide neuroprotection under in vitro conditions of oxidative stress. Therefore in this work, Ca is replaced by strontium (Sr) and yttrium (Y) and cerium (Ce) are incorporated at the expense of sodium (Na) in a 0.52SiO2-0.24SrO-(0.24- x)Na2O-xMO (where x = 0.08; MO = Y2O3 and CeO2) glass series. The structure, dissolution behavior and antioxidant capacity are first investigated for the glass series where excessive dissolution was found to cause fibroblast and osteoblast toxicity. In an effort to reduce dissolution, thermal processing was employed to create a glass-ceramic series. The glass-ceramic structure reduced solubility and eliminated osteoblast toxicity while maintaining a degree of ROS scavenging capacity. Studies evaluating the glassceramic bioactivity and in vitro observation of the interaction of these glass-ceramics with osteoblast and Schwann cells were then completed.
Advisory Committee Members: Anthony Wren, Alexis Clare, Matthew Hall, Nathan Mellott Dissertation completed in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Materials Science Engineering at the Inamori School of Engineering, New York State College of Ceramics at Alfred University