Characterization, Bioactivity and Antioxidant Capacity of Yttrium and Cerium Doped Glass-Ceramics
Date
2016-03
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
New York State College of Ceramics at Alfred University. Kazuo Inamori School of Engineering.
Abstract
Compositional modifications of traditional bioactive glasses were investigated to
address adversity associated with the biological response after spinal cord injury (SCI);
specifically the accumulation of calcium (Ca) and subsequent generation of reactive
oxygen species (ROS). Studies have shown yttria and ceria to have direct antioxidant
scavenging capacity and provide neuroprotection under in vitro conditions of oxidative
stress. Therefore in this work, Ca is replaced by strontium (Sr) and yttrium (Y) and
cerium (Ce) are incorporated at the expense of sodium (Na) in a 0.52SiO2-0.24SrO-(0.24-
x)Na2O-xMO (where x = 0.08; MO = Y2O3 and CeO2) glass series. The structure,
dissolution behavior and antioxidant capacity are first investigated for the glass series
where excessive dissolution was found to cause fibroblast and osteoblast toxicity. In an
effort to reduce dissolution, thermal processing was employed to create a glass-ceramic
series. The glass-ceramic structure reduced solubility and eliminated osteoblast toxicity
while maintaining a degree of ROS scavenging capacity. Studies evaluating the glassceramic bioactivity and in vitro observation of the interaction of these glass-ceramics
with osteoblast and Schwann cells were then completed.
Description
Advisory Committee Members: Anthony Wren, Alexis Clare, Matthew Hall, Nathan Mellott
Dissertation completed in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Materials Science Engineering at the Inamori School of Engineering, New York State College of Ceramics at Alfred University
Type
Thesis