Investigation of Hydroxyapatite, Bioglass and Silver-Doped Bioactive Glass: Characterization, Mechanical and Chemical Properties

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Bioglass, silver-doped bioactive glass and hydroxyapatite were observed and analyzed to determine their mechanical and chemical properties. These materials are commonly used in the medical field for multiple such as coating on implants and a basis for grafting materials. Bioglass is able to bind to bone and soft tissue which encourages bone growth while the addition of silver to bioglass has demonstrated exceptional antibacterial properties. Hydroxyapatite is commonly used as a coating on prosthetics for its ability to promote a positive bone to implant interface. X-Ray Diffraction and particle size was performed to characterize each material in its powder form. Ethoxylated bisphenol A dimethacrylate (EBPADMA) resin based disks were made containing 20wt% of each biomaterial. The resin disks were immersed in simulated body fluid (SBF) for 30, 45 and 60 days to look for calcification on the surface and pH of the SBF was measured after the disks were removed to identify any changes across the time period. It was observed that the pH gradually became more neutral over time for each material. Scanning electron microscopy (SEM) was used to image calcification on the surface of the disks placed in SBF. Energy-Dispersive X-ray spectroscopy (EDX) was used to analyze elements present on the surface of the disks. S. aureus and E. coli cells were cultured and used to observe antibacterial properties of the silver-doped bioactive glass disks. Compression cylinders, with the same composition, were tested using an Instron machine. It was found that each material had higher yield strength than just the pure resin cylinder.
Thesis completed in partial fulfillment of the requirements for the Alfred University Honors Program.
Honors thesis, Bioglass, Hydroxyapatite, Biomaterials