Wren, AnthonyKeenan, TimothyPlacek, LanaCoughlan, Aisling2022-09-232022-09-232022-04Placek LM, Keenan TJ, coughlan A, Wren AW. Synthesis, Processing and the Effect of Thermal Treatment on the Solubility, Antioxidant Potential and Cytocompatibility of Y2O3 and CeO2 doped SiO2-SrO-Na2O Glass-Ceramics. Journal of Biomaterials Applications. 2022;37(1):102-117. doi:10.1177/08853282221078448http://hdl.handle.net/10829/24852This is the Accepted Manuscript of the following article: Placek LM, Keenan TJ, coughlan A, Wren AW. Synthesis, Processing and the Effect of Thermal Treatment on the Solubility, Antioxidant Potential and Cytocompatibility of Y2O3 and CeO2 doped SiO2-SrO-Na2O Glass-Ceramics. Journal of Biomaterials Applications. 2022;37(1):102-117, which has been published in final form at https://doi.org/10.1177/08853282221078448. The article is protected by copyright and reuse is restricted to non-commercial and no derivative uses.Thermal treatment of a 0.52SiO2-0.24SrO-0.24-xNa2O-xMO glass-ceramic series (where x = 0.08 and MO = Y2O3 or CeO2) was conducted in order to synthesize yttrium (Y3+) and cerium (Ce3+) crystalline species that may act as radical oxygen specie (ROS) scavengers. The prominent phase for the Control is a sodium-strontium-silicate while the experimental glass-ceramics (HY, YCe, and HCe) present sodium-Y/Ce-silicate and oxide phases. Disk shrinkage during thermal processing ranges from 1–7% for Control, HY, YCe, and HCe in both diameter and thickness. Solubility studies determined that the release of Si4+ and Na+ are greatest from the Control disks which peaks at 1550 µg/mL. Release from the Y3+ and Ce3+ glass-ceramics reached 320 µg/mL for Si4+ and 630 µg/mL for Na+. The range of antioxidant capacity (ABTS assay) for all samples was 0.31–3.9 mMTE. No significant reduction in MC 3T3 Osteoblast cell viability was observed for any composition tested.en-USJournal Article